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Using the pKa values given in the table on the right, determine the charge of the side group of the following amino acids at the pH specified. Consider the side group only (not including the charges at the C–terminal or N– terminal).
2. Using the pka values given in the table on the right, determine the charge of the side group of the following amino acids
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Answer #1

Charge on side groups of given amino acids:

At pH 3 :

  • Tyrosine (-OH side group ): 0
  • Cysteine (-SH ) : 0
  • Lysine (NH3+) : +1
  • Aspartate (-COOH) : 0
  • Alanine (-CH3) : 0

At pH 10 :

  • Tyrosine : ~0 [- 0.2 ]
  • Cysteine : -1
  • Lysine : 0
  • Aspartate (-COO- ): -1
  • Alanine : 0
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