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Calculate the net charge of a peptide sequence W-S-N-G-C-H (all connected : Tryptophan-Serine-Asparagine-Glycine-Cysteine-Histidine) pKa values at...

Calculate the net charge of a peptide sequence W-S-N-G-C-H (all connected : Tryptophan-Serine-Asparagine-Glycine-Cysteine-Histidine) pKa values at (a) pH 2.0, (b) 6.0 (c) 7.0 and (d) 11.5. Assuming the ionisable groups have pKa values of His 6.0, Asp 3.6, Tyr 10.0, Cys 8.3, Arg 12.5, Lys, 10.5, Glu 4.3 C-term -COOH 2.0, N-term -NH3 + 9.5.

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Answer #1

When pH is lower than pKa of group then group will exist in protonated form and if pH is greater than pKa then group exist in deprotonated form.

a) At pH 2.0, net charge is +1.

b) At pH 6.0, net charge is +1.

c) At pH 7.0, net charge is 0.

d) At pH 11.5, net charge is -2

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