Question

Presume that after graduation you land a much-coveted job at Acme Pharmaceuticals. The chief of the endocrine section asks you, the fresh blood, to present at the weekly lab meeting hypotheses about two candidate genes, polymorphisms in which will predispose people to developing atherosclerosis. Please do not choose PCSK9 or the LDL-receptor. Describe what you will present.

Note: please understand that this is a biochemistry question. Please answer the question by explaining related cellular and molecular pathways. The answer needs to very detailed that it should be minimum of 1000 words or 2 pages.

Answer 1

Answers: the development of Artherosclorosis is a Multifactorial process involving interactions of Multiple genetic and environmental factors. It is Characterized by endothelial dysfunction, build dipids, voscular inflammation, deposition of colcium, Cholesterol and cellular debris within the intima of the vessel wall leads to hardening and thickening a vissches and decreased Blood Supply Two Grences polymorphism involve in succepibility to Artherscleridis Ave. eNlos que – endothelial mitric oxide Sporthall Cenlos) has an Atheroprotective effect. No produced in endothelium leods to vosodilation of endothelium. And promote proper Glood flow in the Arteris.al there is constriction of Arteries due to low Noa production

so there will be more turbulence in Blood flow, more Chances of formation of Autheroscleorsis. polymorphism in enlos 298 Glu/Asp polymorphish Cousis low No production, thus Results in. Hypertension, thrombus development and finally leading to Atherosclerosis. 2 MTHER polymorphism: high homolystein level of the plosma con destroy the endothel Cells of the small Arteries, and thus lead to Atherosclorosis . MTHER leads to elevated homolysteine levels. Elevated homocysteine levels Cause Irritation of the Blood vessels ondare Considered a Risk factor for Blood clots. Thus Individuals with MTHFR Mutations who have normal homocysteine levels are mot at Increased Risk for clots. the MTHER (6777 enzyme plays an important roleri the high plosma homocystein levels. It genotype is usually Associated with higher homolystin levels cincrease the risk of Atheroscloosis.