Question

Nerve gases act by targeting ACE; the agent irreversibly binds to the enzyme resulting a buildup of ACh with the result that the nerve affected is continuously held in the "on" state. Structures of ACh and some nerve agents are given below. Propose a mechanism for ACE deactivation by these nerve agents which accounts for the observation that VX and VE are at least 100-fold more toxic that Sarin. Nt ACh Sarin VX VE

Answer 1

Achve site Cshiolina and SerinAQ

classmate Date Page Glu Galy His te site bindina to seriha