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When performing Electrophilic Aromatic Substitution what do we substitute first the activating or deactivating group?

When performing Electrophilic Aromatic Substitution what do we substitute first the activating or deactivating group?

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Answer #1

activating group.

To undergo electrophilic aromatic substitution; electron density over the aromatic ring should be in electron rich. Electron donating group increases electron density over aromatic ring Electron withdrawing group decreasses electron density over aromatic ring Reactivity after substitution of electron withdrawing group decreases. So, Activating group should undergo substitution first.

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