Question

to simplify question I have made it multiple question

a. What is accomplished during genome assembly?

b.How can protein homology assist in genome annotation

c. What is the principle of Maldi-TOF?

d. What is a homologous gene, gene family?

e. Contrast gene paralogs with gene orthologs

Answer 1

a. What is accomplished during genome assembly?

• Chromosome gets fragmented, sequenced and these sequences have been put together to form a genome sequence.
• Ensembel get produced after genome assembly of fragmented chromosomes.

b.How can protein homology assist in genome annotation

• Genome homology helps in identifying the locations and coding regions of the genes based on their homology for the purpose of genome annotation.

c. What is the principle of Maldi-TOF?

• Mass analysis is used for bacterial diagnosis using a laser pulse.

d. What is a homologous gene, gene family?

• A sequence possessed by two species shows relationship with each other and the gene has been descended from a common ancestor. Ex. bat wing and leg of a monkey

e. Contrast gene paralogs with gene orthologs

• Gene ortholog is where two species possess the same gene, results in same function in the descendents during course of time.
• These homologous genes found in two different species are called as ortholog genes.
• This orthologs occurs due to speciation.
• Paralogs occurs due to duplication, results in new function in the descedents.