Question

Germinal centers arise within ______ after initial exposure to thymus dependent
antigen in the lymph node
A. 7-10 days
B. 24 hours
C. 1 month
D. 1 hour

Blood-borne antigen is filtered by the ______
A. Spleen
B. Liver
C. B Cells
D. Heart

67. What is the most widely used carrier protein?
A. flagellin
B. antibiotics
C. LPS
D. BSA

68. Secondary response has a shorter _____
A. Clonal selection
B. Lag period
C. Ab secretion
D. TLR

69. B cell co-receptor is made up of what cell membrane molecules
A. TAPS-1
B. CR2
C. CD19
D. All of the above
70. Cross Linking of BCR complexes triggers phosphorylation of _____ on Igα and Igβ
A. antigens
B. ITAMs
C. MHC
D. immunoglobulins
71. B cell activation without the direct participation of T h cells
A. Thymus independent antigens
B. Class switching
C. Affinity maturation
D. Antigen presentation
72. Naive B cells are at what stage of the cell cycle?
A. S phase
B. M phase
C. G 2 phase
D. G 0 phase

Answer 1

1. 7 -10 days

The germinal centers tend to arise post 7 to 10 days after the lymph node is exposed to the thymus independent antigen. They are localized within the secondary lymphoid organs and helps in the proliferation of the antibodies. They tend to activate the follicular B cells with help of the antigen.

2. Spleen

The blood is filtered before it is circulated and hence all the blood borne antigens are filtered with help of the spleen. It is an lymphatic organ and helps in the production of the antibody and hence starts an immune response against the antigens.

68. Flagellin

The flagellin is one of the most commonly used carrier protein which helps in production of many vaccines. The protein is a globular protein derived from the flagella of gram negative bacteria and helps in transport making it a popular choice for carrier protein.