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1. [05 pts.] Draw the chemical equation for preparation of Aspirin. (No mechanism) 2. [15 pts.)...


1. [05 pts.] Draw the chemical equation for preparation of Aspirin. (No mechanism) 2. [15 pts.) Show the detailed mechanism m
1. [05 pts.] Draw the chemical equation for preparation of Aspirin. (No mechanism) 2. [15 pts.) Show the detailed mechanism movement of electrons. for reaction. Show all arrow to indicate 3. [09 pts.] Briefly explain the roles of Salicylic acid, Acetic anhydride and phosphoric acid in the reaction. 4. [05 pts.] What type of reaction is preparation of Aspirin? 5. [06 pts.] Briefly describe esterification and give an example using Acyl chloride as one of the reactants.
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COOH СОН Salicylic acid сне, Acetic Anhydride Acetyl salicylic . Acid ( Aspirin) 2. Mechanism - : ОН а адек, и т. COOH 1Бу от

3.  The -OH group in salicylic acid make it nucleophile.

The carbonyl group of acetic anhydride provide the site for nucleophilic attack.

Phosphoric acid act as catalyst for this reaction.

4. The reaction of aspirin preparation is esterification reaction.

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