Question

Lab Section Nume Preparation and Examination of a Drug: Aspirin EXPERIMENT 25 OBSERVATIONS AND RESULTS 1. The Synthesis of Aspirin Record the weight of your aspirin, and calculate the percentage yield. Base the yield on salicylic acid since we acetic anhydride was used. Show all calculations. Weight of aspirin d. 08035 Yield of aspirin 2. Contaminants in Aspirin What was the color of the salicylic acid-ferric chloride test solution? On the basis of color is either your aspirin or commercial aspirin contaminated with salicylic acid? What is your evidence for contamination? Acetic acid was also formed in the synthesis of aspirin and would be present with aspirin in the reaction micture. Why is it unlikely that your isolated aspirin is contaminated with acetic acid? are the binder in the commercial aspirin in your laboratory? What is your evidence? Asplein as r. Add Daw the structure of suplin. Circle and name the funcional group which makes aspirin cord the pt oferch of the compounds. us aspim Coorum.colspirin Salicylic acid 245

Answer 1

Q)

A)

1.The yeild of aspirin can be derive by (actual yeild / therotical yeild) x 100%

(0.080/6.81) x 100% =1.17%

2.

* After an addition of ferric cholride into salicyclic acid the colour of an solution changes to purple and then both the solution of aspirin changes to yellow colour.

*If the colour changes to an purple it shows that the pure aspirin is form . Where as if colour doesnt changes to purple after adding the solution then that shows that the aspirin is an commericial one.

*For promoting crystallization in it filtration occur which removes the acetic acid and unreacted acetic anhydride from the aspirin .Then again the recrystallization is done which will clear all the contamination from the aspirin so that aspirin can dissolved easily .

*As an binder for commericial aspirin the corn starch and water is used which help in binding and filler along with an lubricant this is added to acetylsalicylic acid .

3.

  

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