Question

8. In glycolysis, Step 6: The Oxidation of Glyceraldehyde-3-Phosphate is thermodynamically unfavorable under standard conditions. To "pull" the reaction forward, Step 6 is coupled with Step 7: The 1st Production of ATP. What is the meaning of the term coupled? Calculate the overall AG" for Steps 6 and 7.

Answer 1

Answer:

In Glycolysis 6 the and 7 the steps having coupling to release ATP .

The detail explanation about what is reaction coupling & how Delta G value comes calculation I attached in Below images go through.
glycolysig-Term coupling The energy released by ATP hydrolysis used to power other reactions in a cell? In most cases, cells use a strategy called "reaction Coupling", in which an energetically favorable reaction is directly linked with an energetically unfavourable reaction. The linking often happens through a Shared Intermediate, meaning that a Product of one reaction is "picked up" and cases as a reachent in the second reaction. When two reactions are coupled they can added together to give an over all reaction, The do of this coupled reaction equal to the sum of the sa values of the Individual reaction A B shax tB CTO AG=Y A 2 CAD Au=x+y

In glycolysis 6th Step is formation of "1,3 bis Phos glycerate". by thing GAPDH engyme. cao OP NAD + P H-C-OH GADPH H-C-04 + NADPH + H #--OP H Gry ceraldehyde- 3- Phosphate 1,3-bisphos glycerate AG= +27 kJ/mol from this 1,3 bis Phos glycerate need to release ATP. but this 113 bis Phop Phogycenate thermodynimecally very weak. So, In second th step phosphate group transfer from 1,3 bis plepeglycerate to and forms ADP to ATP and 3-Phosphoglycerate O- OP C =0 +ADP Phospho glycerate kinage - - 1 4-c-OH м% & ATP cao I H-C-OH - Hop H-C-opl 43 bis Phosgly cerate H 2-Po-ayeale su= -30 kJ/mol So; Au= +27 kJ/mol Aha -30 kJ/mol AG² - 3kJ/mol