
1. (6 pts) Provide reagents for each of the following reactions over the arrows provided. ОН...
4. (3 pts) Using retrosynthetic analysis, provide a synthesis for the following molecule. Place the required reagents next to the arrows and the necessary intermediate in the box provided. Me NH но HK он 1 4 5. 6. 3. 2. NH2 O) 08
4. (3 pts) Using retrosynthetic analysis, provide a synthesis for the following molecule. Place the required reagents next to the arrows and the necessary intermediate in the box provided. Me NH но HK он 1 4 5....
3. Provide the reagents necessary to carry out the following reactions or provide the starting materials or major products of the following reactions, Indicate racemic mixtures where necessary. (39 pts) 1)AIC осн, a. Ph 2) PaC H Н,со 45 1) HS0, HNO b. 2) Pd/c. H Н,со он c. Ph HO, он
Provide reagents for each reaction shown in the
scheme below
(4) (15 pts) Provide reagents for each reaction shown in the scheme below: он он он SH
1) Provide the starting material for the following reaction. (0.5 pts) Он Он 1) Hg(OAc)2, H20 2) NaBH (provide starting material) 2) Provide the major organic product(s) for the following reactions. If stereoisomers are formed, please show both stereoisomers. (0.5 pts each) 1) BH3 THF a) 2)120 NaOH 1) NaOH, H-O, 55°C b) 2) OsO4 t-BuOOH 1-BuOH, NaOH Br2 c) CCl4 H2O, H2SO d) H9SO4 2 equivalents HBr e) 3) The following ction generates an ether. Provide the major organic...
8. Provide the reagents necessary for each of the following transformations. Он но Но. он он OCH3 ОН
19) Predict the reagents for the following synthesis? 6 Pts OH он H A B A B- D- 20) Rank the following Carboxyllic Acid derivatives in decreasing order (Most to Least) of reactivity towards Nucleophillic Substitution reactions? 3 Pts NH II III IV More Reactive: Least Reactive 21) Match the following? 2 Pts 1) Alkynes 2) Aromatic Compounds 3) Aldehydes/Ketones 4) Carboxyllic acid derivatives A) Nucleophillic Addition Reactions B) Nucleophillie Substitution Reactions C) Electrophillie Additon Reactions D) Electrophillic Substitution Reactions
7. (3 pts each) Write the correct reactant, reagents, or major product of the following reactions он TSCI Nal pyridine DMSO HBr EtOK EtOH CH2l2, Zn/Cu Et20 Br2 hv ONa Ph3PBr2 он elimination product Name: Page 6 of
1. Provide the missing starting materials, reagents, or products in each of the following reactions. H+ OH CH,OH NaOH Meo NH2 room temp. HO OH Meo Me ОН Meo 2. Provide appropriate conditions to convert each of the following starting mana hexanoic acid (some transformations may require more than one step): It each of the following starting materials into OH OH ОMe "NH₂
6. Give reactants, reagents, and/or products for the following reactions, as appropriate. SOCI2 он 1) NaBH, (excess) OCH3 2) H307 OH, H20 (excess) 1. CH3CH2MgBr (excess) 2. H30*
3. Provide the regents over the blank arrows below to afford the desired transformations. (8 pts.) он OH H