Question

2. What is the most likely diagnosis, considering the rectangular crystals? What is the underlying structural abnormality?

Answer 1

Because there are more RBC needed in the body at that moment (During Pregnancy) they are released prematurely, leading to polychromasia. & Association with reticulocyte. If low courst of reticulocytes. are found it cessually indicate bone marrow stress. If high reticulocyte count is found it is cessually linked to hemolysis, but a Coombs test may be performed in this case to rule out inmune-mediated hemolysis. * Haemoglobin-c crystals are dense rectangular structures composed of precipitated hemoglobin-c. Numerous target cells and scattered hemoglobin C crystals in a patient with hemoglobin - c disease. Microcytic target cells can be seen in thalassemia and other hemoglobinopathies.

Polychromasia is a disorder. There is an abnormally high number of immature RBC found in blood as a result of being prematurely released from bone marrow during blood formation. These cells shades greyish blue. Polychromasia is essually a sign of bone marrow stress as well as immature RBC. These young cells generally stain grey or or blue in the cytoplasns. These young cells are called Reticulocytes. Causes. RBC can be released prematurely by a number of mechanisms. ③ Association with Anemia Normocytic anemia is the most commonly seen type of anemia. This type of anemia is ussually caused by under production of blood cells as well as Haemolysis. Anemia can be caused by either over production or under production of RBC as well as the production of defective blood Celle