Question

Question 17 6 pts Describe the cascade of events that occurs when ZAP-70 activates the NFAT pathway in T cells.

Answer 1

Answer:

a) ZAP-70 directly activating Tcell

ZAP 70 binds to IRAK4 which activate PKC8.

PKC8 along with P38/JNK and ERK1/2 give activation signal to NFxB

NFxB activate Tcell resulting in production of IL2

b) ZAP-70 activating Tcell via NF-AT

Also ZAP 70 activate PLCr1

Which inturn activate IP3

IP3 along with Ca2+ activate NF-AT which activate Tcell resulting in production of IL2

Please see attached picture.
Antigen presenting STER-COB - PLC ZAP 1P₃ + Cata PK C8 NF-AT » T cell activation IL-2

ZAP- Zeta-Chain & Associated Protein Kinase NEAT- Nuclear Factor of Activated T cells IL - Inter Leukin. PLCY! - Phospholipase C gamma-)