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Identify which cytokines are responsible for the differentiation of CD4+ T cells to Th1, Th2, and Th17 subsets. Also identify
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Answer #1

CD4+ T cells differentiate into

  • Th1 cells : APCs release Interleukin 12 which induces Natural killer cells to release Interferon gamma
  • Th2 cells: IL2 fromactivated CD4+cells and IL4 from ,maybe, basophils
  • Th17 cells : IL6 from APCs, IL 21 from activated T helper cells or NKT cells; IL 23 from, macrophages and dendritic cells . And. TGF-β . from all WBC lineages
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