Researchers examining families with hypercholestemia (high LDL levels) found missense alleles in PCSK9. While researches examining the genomes of individuals with very low LDL levels found nonsense allleles in PCSK9.
I. How does PCSK9 regulate LDL levels?
A. PCSK9 promotes LDL in the blood
B. PCSK9 inhibits LDL level in the blood
C. One cannot tell how PCSK9 affects LDL levels with just this information
D. PCSK9 causes LDL levels to dramatically increase that then drop suddenly
E. PCSK9 causes LDL levels to dramatically decrease and then increase suddenly
II. Given this information what genetic classification would you assign to the missense allele of PCSK9?
A. Amorph
B. Hypomorph
C. Hypermorph
D. Haploinsufficient
E. Silent
Q.1 B) PCSK9 promotes LDL level in The blood (PCSK9 Gene is synthesizing protein which controlling the amount of LDL receptor on cell)
Q.2 hypermorph ( is a type of mutation when the gene is gained the function means synthesize more protein)
Researchers examining families with hypercholestemia (high LDL levels) found missense alleles in PCSK9. While researches examining...