Homework Answers
Answer:
PATHOPHYSIOLOGY Chronic Lymphocytic leukemia -CLL
In B cell.
Here B cell mature under constitutive stimulation of Bcell receptor.
Constitutive means, the gene is always on.
B Cell Receptor stimulation called BCR.
Quantitatively derived from Bcell receptor clustering, constitutive signaling from positive feedback reinforcement.
Here the cell gives autoactivation of signaling.
Alteration in BCR genome.
This results in proliferation of cd 5 and cd 23 B cells.
SYMPTOMS
Fatigue, loss of appetite
Muscular weakness
Bone pain or tenderness
Hepetosplenomegaly
Fever
Lymphnode enlargement
Night sweats
TREATMENT
Chemotherapy is treatment
For young patients with positive IGVH mutation FCR regime.
(Fludarabine, cyclophosphamide, rituximab)
Young non mutated/elderly/ 17p mutation- ibrutinib
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