Question

(a) role of the CFTR receptor in the human body.

(b)

(c)

CFTR receptor in the human body, (B) the role of CTFR receptor and the cholera toxin in development of cholera (diarrhea and dehydration), and (C) the mutation responsible for the vast majority of cystic fibrosis as well as how this mutation results in cystic fibrosis.

Answer 1

A)

CFTR is abbreviated as cystic fibrosis transmembrane conductance regulator. CFTR protein functions as a channel in the membrane cells of the body that produce tears , sweat, mucus .

B)

cholera toxin binds to epithelial cells. Subunit B of this cholera toxin binds with glycolipids exposed on the outside of the host cell, bringing the bacterium and host cell in closer contact. The A subunit can then penetrate the host cell membrane whereby a cascade of intracellular molecular events takes place resulting in higher cAMP and than calcium ions are released through CFTR regualator

C) CFTR mutation that is removal of phenylalanine from 508 position or (F508 deletion)is the mutation responsible for cystic fibrosis