Question

A) Achondroplasia is a type of dwarfism. Knowing that a couple where you both show dwarfism they can have normal children and achondroplasic children, and that a Normal couple cannot have achondroplastic children. Explain how this is inherited disease and the percentage of offspring that would be affected.

B) Galactosemia is a human disease that is inherited from Mendelian simple, like a monogenic recessive character. A woman whose father had Galactosemia is paired with a man whose grandfather was galactosemic. Both of them they are concerned about the possibility of having a galactosemic child. What is the type of inheritance and the probability of it being so?

Answer 1

Normal couple, 0 Couple both showing dwarfism A allele expresses dwarfism whereas a allele is normal. rrier semic, A AA I Aa a Aaaa The punnett square shows that normal AA Lethal couple cannot have Aadwarf achondroplastic children. aa normal Percentage of having Percentage of having dwart normal children is. | 100%. offspring - 2/4 or 50% Percentage of having normal offspring - 1/4 or 25%. is

Women's father had Gralocto semia (gg). Woman's mother was either normal or heterozygous (carrier). If mother was noom. If mother was carrier Gr Tag Gg all children | G laglag being woman is a carrier woman is either a. Carrier or galactosemic, but probability of * Let's say the woman seis being galactosemic is a Carrier. 124 r.e. 20% van Man's grandfather had galactosemia If man's father was galactosemia Cassier, and mother being normall mother being cossier Gog ahalag a. Thalag a ha lag! Probability of man being galacto semic = 25%.

If the man is normal and woman is cassier. If the man is carrier and woman is casier a laalaa a ac ag 1 Normal child 50% Galactosemic child 50% Normal child → 25% Carrier child 50% y Galactosemic child 25%.
For question B, carriers are normal, they do not have galactosemia, they have one normal allele and one galactosemic allele, normal allele dominates over the galactosemic allele. Here, the type of inheritance is autosomal recessive.