Question

what is genetic basis of mutators?

1 defects of homologous recombination

2 chemical or physicalagent that cause mution

3 recA-

4 DNA polymerase mutants

5 mismatch repair mutant

Answer 1

Simply stated, cancer cells exhibit a mutator phenotype. This phenotype is the result of mutations in genes that function in the maintenance of genomic stability. It is manifested by increases in mutation rates and in genetic evolution of cancer cells that drives tumor progression.

Mutator phenotype refers to the increase in mutation rate of cancer cells. The Mutator Phenotype Hypothesis was formulated to account for the disparity between the infrequency of spontaneous mutations in normal cells and the large numbers of mutations observed in human tumors. The hypothesis states that an increase in mutation rate is an early event in tumorigenesis. Some of the random mutations produced throughout the genome are located in genes that normally function to guarantee the accurate transfer of genetic information with each cell division. The expression of this “mutator phenotype” leads to a cascade of mutations throughout the genome including mutations in other genes required for the maintenance of genetic stability. Among the many mutations produced are ones that promote growth, invasion, and metastasis, the hallmarks of cancer.

Mutators are continually produced from nonmutators, often due to mutations in mismatch-repair genes.