Question

Part IV- Why the variation? from Evolving Genetics of Disease resistance by Jennifer Dechaine

If CCR5 affects resistance to HIV, the plague and smallpox,what other disorders might it affect?

Be specific: What do the known diseases that CCR5 affects have in common? How are they different?

Are there diseases that CCR5 is unlikely to affect? Which ones and why?

Answer 1

Page) Hin strains that use this coreceptor are hered to as Rs Vizures. Polymorphisms in the Coding & Non Coduing regions of the CCR5 gene influence the natural history of HIV infection ; ERR CCRS for cecks) stands for the ce chemokine receptor 5.c.c chemoterie receptor type 5 , also known as a CCRS Ö colas, iš'a porlosis on the Surface of W.B.c' that are involved in the Immune - of wat as it acts as a nd the Deltasa Continue populations fro people bei cherchie The schoolane samples cers com mutation, something in the genetic deletion of a portion of the ceRs gine. ga worldwide prominence a decade ago when it was identified as one the major Coreceptor Hiu infectivity. However subsequent studies important modulatory role cers in the inflammatory response... Sugosted on impor sponse eported to CERS has be Tall om. in auto direct le regulate immine Lucase, inducing multiple sclerosie shematoid arthritis , & type 1 diabeties, More quer, T collo meduoled immune se pers

Page - 2 are proposed to be caritical in the pathogenesis of cutoimmune fille sal liver Liseases, & recent clinical & Experimental studies have also implicated ceRs in the utoimmune genesis pathogenesis of autoimmune & Viral letno direases. • HBU G HCV are haptotropic Visues that replicate marily in the liver. Is both infections, liver damage occurs as a Consequence of the immune susponse to liaus present within the liver Oier zoomillion people worldwide are persistently infected with HBUEHEN Tower devaie, developing chronic liver disease, Cirrhosis, 's hepatocellulari Carcinoma. Despite many comiron features in their pathogensis, HBV & Heu differ markedly in their linological properties, as well as in their immune escape & Survival stratega! Although hbu is a DNA Virus where as he is an RNA claus, Similar cell. have been implicated in the pathogensis of both liver diseases, Althoud animal models $ HBV infections are well characterized, the role of cers in the pathogensis & clinical

25 SI 2U CCR5 J De perilous de numero mene surmasis wordtermined. There şi faperiruntal compopel modelo me role of.cers in the pathophysiology of lined topatikis irdued by '4cw. +39 3 A sole for cers has been suggested in numerow duriais, many infusing the musicais Stylero, coros ligands au produced in the, ents by microglia, astrocytes, ardaithe line olls- & even neurons. Most likely , CCR5 facilitates the clearance at there infections ty ponsmarting Lue koryte 10 ukers to the cals, proof of het hout fuman health ceng may pinahund be de tomimantead in patients with Caxabral nalaria, in brainst Samples of whom it was found to be up rege related. The CCR5032 allele seems to be accialed with resistance to Gimean - Congo herroofagic feuer {CCHE) Ulises tection at least in the Turkish population, indend, cec3, celu, access natural ligands of cers, axe auocated with (CHF, & their levels are increased in adult of its beneficial of "

gle revaino: ectous desease, palarks with the infection. I Page-4. In an einerging infectious disease, degus Virus infection, as association has been found with CcR5 expresion, & the infection includes the expression of cers ligards. n 8 beint Хр Samas please give a positive vete