Homework Answers
1)Cdc 20 usually form a complex with mad 2 and APC blocking the early activation of APC. If Cdc 20 is mutated and loose the capacity to bind to Mad 2 APC will bw activated throught the cell cycle and the cell will divide before the metaphase alignment is proper.This can lead to the formation of and abberated cell showing non disjunction of chromosomes
2)If Cdc 20 fails to bind with APC the result will be same as mentioned above due to the inappropriate activation of APC.
3)If Cdc 20 fails to disscociate from APC at the end of anaphase mitosis will be arrested and the cell cannot divide.
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Metaphase to Anapnase uneckpoint 4. Predict the phenotype that you would expect of a cell whose...
1.) In a small number of patients whose families appear to have all the classical characteristics...
1.) In a small number of patients whose families appear to have
all the classical characteristics of FAP, a mutation cannot be
found in the APC cDNA. What are two possible reasons for why
mutations may not be found in some patients whose families appear
to have FAP?
2.) Using the diagrams of APC domains and interactions provided
in the case study, hypothesize the most likely effect of this
mutation on APC ability to perform its function within the protein...
The picture below represents a cell during metaphase of mitosis. The chromosomes are represented in red...
The picture below represents a cell during metaphase of mitosis. The chromosomes are represented in red and the mitotic spindle is represented in green. BO ! A. The cell is stuck in metaphase because a checkpoint has been activated. Why was the checkpoint triggered? B. What could have happened to this cell without this checkpoint? There are three main checkpoints during the cell cycle. One checkpoint occurs at the end of G1 phase and involves the protein p53. If p53...
You are a studying the progression of cells through the cell cycle. You are particularly interested...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcia...
As a continuation of the experiments in Question 1 you want to study the timing of...
As a continuation of the experiments in Question 1 you want to study the timing of the APC's activity more distinctly. To do this you treat your cells with MG132 - a proteasome inhibitor. When MG132 is added to cells proteins can still be ubiquitinated, but they are not degraded, because the proteasome is inhibited. In cells that are treated with MG132 you can monitor APC activity on Cyclin B using just the cyclin B a. antibody and a western...
Bookmarks Window Help proteins would Which of the fo -CELL BIOLOGY (BIOL408005)-1192 Question Completion Status: Which of the following proteins would you classify as a tumor suppressor (a protei...
Bookmarks Window Help proteins would Which of the fo -CELL BIOLOGY (BIOL408005)-1192 Question Completion Status: Which of the following proteins would you classify as a tumor suppressor (a protein that prevents cancerous uncontrolled growth)? the kinase Wee1 APC the phosphatase cdc25 M-CDK QUESTION 10 Which of the following proteins would you classify as a proto-oncogene (a protein that can promote uncontrolled growth)? the phosphatase cdc25 the kinase Wee1 the anaphase inhibitor the cohesion protein Click Save and Submit to save...
3. (4 points) Briefly describe the path a protein made by ribosomes that are attached to...
3. (4 points) Briefly describe the path a protein made by ribosomes that are attached to the endoplasmic reticulum will follow through the endomembrane system in order to be exported from the cell. Include in your answer which other organelles the protein will move through, how the protein is moved from one organelle to another, and the process that a cell would use to export the protein. 4. Fill in the diagram below with what you learned about the cell...
D7. Looking at your staging results, which phase of the cell cycle does the cell spend...
D7. Looking at your staging results, which phase of the cell cycle does the cell spend the most time in? interphase prophase metaphase anaphase telaphase cytokinesis 8. if we were using slides from a frog instead of an onion to do this lab, which cell type do you think would be best for us to view mitosis? frog skin frog embryo frog brain frog muscle D5. You want to use PGLO to produce red fluorescent protein (RFP) instead of green...
Part IV—The APC Protein “Sam, I’m really worried about seeing my test results today,” Jane said...
Part IV—The APC Protein “Sam, I’m really worried about seeing my test results today,” Jane said as they headed in for another visit with their genetic counselor. “After Ms. Meeker explained your results to us, I’ve been dreading hearing whether or not I have the mutation too.” Sam nodded, saying, “I can understand how you feel. I’m glad I can be here at the appointment to support you. Whatever happens, you know your family is here for you.” Ms. Meeker...
QUESTION 5 At the end of the cell division occurring here, what would you expect to...
QUESTION 5 At the end of the cell division occurring here, what would you expect to happen? OO A. A nucleus to form around each set of DNA B. 4 cells of equal size C. 1 large cell and 3 small cells D. A septum ring to form, separating 2 cells QUESTION 6 During the G2 stage of interphase, -_does not occur. A. organelle replication B. DNA growth C. protein replication D.cell growth
1.) In a small number of patients whose families appear to have
all the classical characteristics of FAP, a mutation cannot be
found in the APC cDNA. What are two possible reasons for why
mutations may not be found in some patients whose families appear
to have FAP?
2.) Using the diagrams of APC domains and interactions provided
in the case study, hypothesize the most likely effect of this
mutation on APC ability to perform its function within the protein...
The picture below represents a cell during metaphase of mitosis. The chromosomes are represented in red and the mitotic spindle is represented in green. BO ! A. The cell is stuck in metaphase because a checkpoint has been activated. Why was the checkpoint triggered? B. What could have happened to this cell without this checkpoint? There are three main checkpoints during the cell cycle. One checkpoint occurs at the end of G1 phase and involves the protein p53. If p53...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcia...
As a continuation of the experiments in Question 1 you want to study the timing of the APC's activity more distinctly. To do this you treat your cells with MG132 - a proteasome inhibitor. When MG132 is added to cells proteins can still be ubiquitinated, but they are not degraded, because the proteasome is inhibited. In cells that are treated with MG132 you can monitor APC activity on Cyclin B using just the cyclin B a. antibody and a western...
Bookmarks Window Help proteins would Which of the fo -CELL BIOLOGY (BIOL408005)-1192 Question Completion Status: Which of the following proteins would you classify as a tumor suppressor (a protein that prevents cancerous uncontrolled growth)? the kinase Wee1 APC the phosphatase cdc25 M-CDK QUESTION 10 Which of the following proteins would you classify as a proto-oncogene (a protein that can promote uncontrolled growth)? the phosphatase cdc25 the kinase Wee1 the anaphase inhibitor the cohesion protein Click Save and Submit to save...
3. (4 points) Briefly describe the path a protein made by ribosomes that are attached to the endoplasmic reticulum will follow through the endomembrane system in order to be exported from the cell. Include in your answer which other organelles the protein will move through, how the protein is moved from one organelle to another, and the process that a cell would use to export the protein. 4. Fill in the diagram below with what you learned about the cell...
D7. Looking at your staging results, which phase of the cell cycle does the cell spend the most time in? interphase prophase metaphase anaphase telaphase cytokinesis 8. if we were using slides from a frog instead of an onion to do this lab, which cell type do you think would be best for us to view mitosis? frog skin frog embryo frog brain frog muscle D5. You want to use PGLO to produce red fluorescent protein (RFP) instead of green...
QUESTION 5 At the end of the cell division occurring here, what would you expect to happen? OO A. A nucleus to form around each set of DNA B. 4 cells of equal size C. 1 large cell and 3 small cells D. A septum ring to form, separating 2 cells QUESTION 6 During the G2 stage of interphase, -_does not occur. A. organelle replication B. DNA growth C. protein replication D.cell growth
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