Question

Match the type of DNA lesion with its repair system. Note: Aflatoxin is produced by a mold that grows on crops, such as peanuts. Before FDA regulation, it used to be found at significant levels in peanut butter. The adduct is shown below: . HN HON NH d RIBOSE Uracil ✓ [Choose ] Nucleotide excision repair Mismatch repair Base excision repair The base pair resulting after a 5-methyl- cytosine deamination event Aflatoxin adduct [Choose]

Answer 1

Uracil adducts are normally repaired by base excision repair (BER), with mismatch repair as a back up for U:G mismatches.

Aflatoxin adducts are repaired by nucleotide excision repair (NER).

MATCHING:

DNA LESION	REPAIR SYSTEM
Uracil	Base excision repair
The base pair resulting after a 5-methyl-cytosine deamination event	Mismatch repair
Aflatoxin	nucleotide excision repair