Homework Answers
Calcium channel blockers are used widely an as anti-anginal agents. They relieve coronary artery spasms by thge following mechanism:
For that let us firstly understand the mechanism of calcium channel blockers(ccb) :
*CCBs block voltage sensitive Ltype Calcium channels by binding to alpha-1 subunit
*thus preventing entry of calcium into the cell
* no excitation contraction coupling in the heart and its vascular smooth muscles.
drugs like Verapamil, DIltiazem, and the dihydropyridines ( such as nifedipine, amlodipine, felodipine,etc. ) are the CCBs that can be used as an anti-anginal drugs.
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pharmacology
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pharmacology
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