Question

Protein kinase A, B, C, What do these proteins have in common? How are they different?

Quick question. thanks!

Answer 1

Ans:

Similarities between Protein kinase A, B and C

1) All the protein kinases A, B and C are involved in phosphorylation and are made of Serine/ Thereonine amino acid residues.

2) All three protein kinases are involved in the function of transcription.

Differences

1) Function

Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

Protein kinase B plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation and cell migration.

Protein kinase C is involved in receptor desensitization, in modulating membrane structure events, in regulating transcription, in mediating immune responses, in regulating cell growth and in learning and memory.

2) Activation:

Protein kinase A gets activated by high levels of cAMP.

Protein kinase B gets activated by high levels of growth factors and hormones.

Protein kinase responds to levels of Ca+2 ions and diacylglycerol levels.