Question

The correct folding of proteins is necessary to maintain healthy cells and tissues. Unfolded proteins are responsible for such neurodegenerative disorders as Alzheimer's, Huntington's, and Creutzfeld-Jacob disease (the specific faulty protein is different for each disease). What is the ultimate fate of these disease causing, unfolded proteins? A. They form structured filaments, B. They form protein aggregates. C. They bind a different target protein. D. They are degraded.

Answer 1

The correct option is (d)

It is because the synthesis of misfolded proteins due to spontaneously following a wrong folding pathway. These misfolded proteins create a disbalance for the secretion of new proteins. So, these proteins are either made to fold into their native structures. In case, the proteins dont refold, they are ultimately exported out of endoplasmic reticulum, and then finally degraded by proteasome.

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