Question

Which of the following is a correct about how lymphocytes in the Adaptive Immune System acquire millions of possible combinations of antibodies?

		Vertebrate genomes have millions of different antibody genes, which are constantly being transcribed and translated.
		After differentiation, a small number of immunoglobin genes in each lymphocyte undergo internal recombination to create a unique antibody for each B-cell or T-cell.
		RNA interference cleaves viral nucleotide sequences, then uses them as a template to produce special antibodies that can target diverse antigens.
		Individual B-cells and T-cells constantly produce multiple different types of antibodies, which they simultaneously express on their membranes, until they match an antigen.
		None of the above.

Answer 1

Date: Page no: 1 Answer is :- Aften differentiation a small number of Immunoglobin gene in each lymphocyte undergo Linternal recombination To create a unique Antibody for each 6-cell or T-cell Explanation : - Combinatorial vols reining: Random a sno ciation of any v gene segment with any I gene Segment can occur to form an L chain variable region and similanly any v can asoociate with any oors gene segment in The H chain gene rearrangment AS There are about your and 55k gene coding for The K chain variable region, asoome random danociation Then yox 5 or 2ooks chain can be formed. Soma 6 junchonal flexibility in during the reining of Antibody gen segment , a variable number of nucleotide are often dost from the ends of the recombination gene segment and one or more randomly chosen nucleotide may also inserted This random Joss and gain of nucleohde at Toining site is called Junction diversification. fic hype, motation 1 Rake of Recombination is very ligh) Combinatorial joining hand h chain Treene Jocool - reanang mena) +> |0-0-5 reestangment recombination somatic by TRAY) recombination Transcription engame (Tramadation somatic