Question

How can poisons alter cell signaling? Give an example.

Answer 1

Answer :- An important aspect of host-pathogen systems is the mechanism by which toxins secreted by many pathogenic organisms change the signaling events by associating them with host cell receptors to increase cellular cAMP concentrations, resulting in aberrant activity or death of cells.

The molecular mechanism underlying a toxin interaction with a signaling cascade is directed towards a specific target on the cell membrane where a normal physiological reaction is triggered by standard signals or second messengers. Certain toxins act as pores that interfere with the intracellular ionic equilibrium and collapse.

Dermal Toxicity may occur when a toxicant reaches direct contact with or is internally transmitted to the skin. Effects range from mild discomfort to serious changes including irreversible damage, hypersensitivity, and skin cancer.