Binding of IL6 by its receptor results in which of these cellular responses? a) Activation of...
Binding of IL6 by its receptor results in which of these cellular responses?
a) Activation of JAK
b) Translocation of STAT3 into the nucleus
c) All of these
d) Phosphorylation of STAT3
Homework Answers
interleukin 6 binds to its receptor then JAK on the receptor is phosphorylated, then it phosphorylates STAST-3, phosphorylated STAT-3 dimerizes and translocates into the nucleus, and changes the gene expression so the answer is c) all of these.
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Binding of IL6 by its receptor results in which of these
cellular responses?
a) Activation of...
Which of the following sequences is correct? a. binding of a signaling molecule to its receptor...
Which of the following sequences is correct? a. binding of a signaling molecule to its receptor → G protein activation → phospholipase C activation → IP3 production → increase in cytoplasmic calcium concentration b. binding of a growth factor to its receptor → phosphorylation cascade → activation of transcription factor → transcription c. diffusion of a signaling molecule across the plasma membrane → binding of the signaling molecule to its receptor → movement of the signaling molecule-receptor complex into the...
Which is NOT true of RTK activation A. A dominant-negative mutation of the receptor showed that...
Which is NOT true of RTK activation A. A dominant-negative mutation of the receptor showed that autophosphorylation was possible B. Whole antibody showed that crosslinking receptors was able to activate them C. Fab fragments showed that binding alone was not what activated receptors D. Activation of the receptor is accomplished when tyrosines on the tail of the receptor are phosphorylated
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein...
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
T cell activation results in all of the following except. (a) activation of cellular mitosis genes,...
T cell activation results in all of the following except. (a) activation of cellular mitosis genes, (b) release of cytokines stored in cytoplasmic granules, (c) new mRNA synthesis, (d) mitosis, (e) new cytokine production.
Glucagon can induce several changes in second messengers that alter cellular metabolism. Which changes in second...
Glucagon can induce several changes in second messengers that alter cellular metabolism. Which changes in second messenger(s) are correct? A. Acetylation of Insulin receptor B. Synthesis of cNAD+ C. Depilitation of Insulin Receptor D. Altering the Km for insulin binding to Insulin Receptor E. Induction of cAMP and phosphorylation of Phosphorylase A
7a) Outline the two major cellular process/pathways activated by binding of EGF binding to the EGF-receptor...
7a) Outline the two major cellular process/pathways activated by binding of EGF binding to the EGF-receptor within cells? b) Signal transduction during cell signaling events frequently involves the action of kinases and phosphatases. Describe how these proteins function to regulate the action of individual proteins.
please make sure to draw not just explain Ligand binding to certain receptor tyrosine kinases results...
please make sure to draw not just explain
Ligand binding to certain receptor tyrosine kinases results in the activation of a sphingomyelinase enzyme. Draw the reaction that shows the sphingomyelinase catalyzed hydrolysis of sphingomyelin to ceramide.
QUESTION 5 A series of glucocorticoid receptor (GR) CDNA or its mutants linked to B-Galactosidase (Gal)...
QUESTION 5 A series of glucocorticoid receptor (GR) CDNA or its mutants linked to B-Galactosidase (Gal) were transfected into cells and tre dexamethasone. B-Galactosidase was assayed in the nucleus and cytoplasm of cells. B-Galactosidase activity was found in the transfectants containing the following: O GR CDNA-bGal O GR ligand binding domain-bal O GR DNA binding domain-bGal O GR activation domain-bGal O GR flexible domain-bGal O A and B OC,D,E O A, B, C, and D all of the above
The PDGF receptor is a proto-oncogene (a normal cellular gene that becomes oncogenic when mutated). Which...
The PDGF receptor is a proto-oncogene (a normal cellular gene that becomes oncogenic when mutated). Which statement about the PDGF receptor is true? A. The oncogenic mutation constitutively represses the intracellular kinase activity of the protein. b. The oncogenic mutation occurs at the intracellular amino terminal end of the receptors. c. The oncogenic mutation generates a receptor that is no longer dependent on ligand for activation.
Ligand binding to a G-protein coupled receptor (GPCR) results in activation of a single G- protein and then the receptor deactivates. O True False When an activated receptor relays the signal along more than one pathways this is called convergence. O True OFalse Which of the following best describes digestive enzymes? O Hydrolases OLigases Kinases Transferases Decarboxylases Most digestive enzymes are released from cells in an inactive form. True False denatures Protein digestion in humans (and other mammals) begins in...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...
T cell activation results in all of the following except. (a) activation of cellular mitosis genes, (b) release of cytokines stored in cytoplasmic granules, (c) new mRNA synthesis, (d) mitosis, (e) new cytokine production.
please make sure to draw not just explain
Ligand binding to certain receptor tyrosine kinases results in the activation of a sphingomyelinase enzyme. Draw the reaction that shows the sphingomyelinase catalyzed hydrolysis of sphingomyelin to ceramide.
QUESTION 5 A series of glucocorticoid receptor (GR) CDNA or its mutants linked to B-Galactosidase (Gal) were transfected into cells and tre dexamethasone. B-Galactosidase was assayed in the nucleus and cytoplasm of cells. B-Galactosidase activity was found in the transfectants containing the following: O GR CDNA-bGal O GR ligand binding domain-bal O GR DNA binding domain-bGal O GR activation domain-bGal O GR flexible domain-bGal O A and B OC,D,E O A, B, C, and D all of the above
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