Homework Answers
A) drug 1 has better binding affinity with enzyme at conc. above 2nM which showing maximum binding of drug to enzyme whose value is 1 while drug 2 does not showed good binding affinity with enzyme even at higher conc.
So Drug 1 has better potential to interest with enzyme
B) both drug required RNA for binding with enzyme which indicates that these drug are inhibitor of RNA binding protein and can block RNA replication which could be better killing or inhibiting ability as HIV is having RNA as genetic material.
Hope it's clear..thanks
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O Fraction of Enzyme bound to Inhibitor HIV enzyme named above New Drug 1 OHIV enzyme...
Interpret this data. Why do you think bone marrow cells would be affected more than other...
Interpret this data. Why do you think bone marrow cells would be
affected more than other cell types?
4. The data below helps us to understand both how AZT affects the enzyme that you named above and how it may affect other cells. Interpret this data in light of your answers to the previous questions. Why do you think bone marrow cells would be affected more than other cell types. Fraction of Enzyme bound to Inhibitor Human DNA dependent RNA...
4. A) At high doses, AZT had serious side effects especially on bone marrow cells. Based...
4. A) At high doses, AZT had serious side effects especially on bone marrow cells. Based on the structure of AZT and how you think the inhibitor works, what do you think is the cause? B) The data below helps us to understand both how AZT affects the enzyme reverse transcriptase and how it may affect other cells. Interpret this data in light of your answers to part a. Why do you think bone marrow cells would be affected more...
At pharmaceutical companies the goal of many drug discovery experiments is to find improved drugs over...
At pharmaceutical companies the goal of many drug discovery experiments is to find improved drugs over existing drugs that bind to a target protein of interest. The graph below shows how "Drug A" binds to a target protein 1. Protein-Ligand Binding Curve for "Drug A" 1 0.9 0.8 0.7 0.6 Y 0.5 0.4 0.3 0.2 0.1 0 0 10 15 20 25 30 35 40 From the graph, estimate the Kd of "Drug A" for the target protein. Report the...
Similar to the lecture, our example is a drug molecule D and a drug target enzyme...
Similar to the lecture, our example is a drug molecule D and a drug target enzyme E. The drug target enzyme E is commonly found in concentrations [E]tot of 250 nM, i.e. 2.5 x 10-7 mol/l. The drug D binds to E to form the complex ED with a dissociation constant of KD = 1.30 µM (i.e. 1.30 x 10-6). The dissociation constant has been determined at room temperature, i.e. for T = 298.15 K. 1. In order to estimate...
Please help me with these two problems. I will rate the answers. 1. The HIV-1 protease,...
Please help me with these two problems. I will rate the
answers.
1. The HIV-1 protease, an important enzyme in the life cycle of the human immunodeficiency virus-1 (HIV-1), is a good drug target for the treatment of HIV and AIDS. A protein produced by the virus, p6*, is an HIV-1 protease inhibitor. The activity of the HIV-1 protease was measured in the presence and absence of p6* using an assay involving an artificial substrate, as shown below. NH Lys...
Homework # 16: Enzymes Late assignment will be given a grade of "0. Due Date 1. An enzyme is primarily made out of a (hint what food group). catechol+ oxygen (0a) Catecholasepolyphenol 2. Loo...
Homework # 16: Enzymes Late assignment will be given a grade of "0. Due Date 1. An enzyme is primarily made out of a (hint what food group). catechol+ oxygen (0a) Catecholasepolyphenol 2. Looking at the equation above, the enzyme in this reaction is: 2. A. Catechol B. Oxygen C. Catecholase D. Polyphenol 3. Looking at the same equation as question 2, what is the substrate? A. Catechol B. Oxygen C. Catecholase D. Polyphenol What is the name of the...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
2. Captopril was the first of a class of blood-pressure lowering drugs that work by reversibly...
2. Captopril was the first of a class of blood-pressure lowering drugs that work by reversibly inhibiting Angiotension-converting enzyme (ACE). Later to the market was Lisinopril. This class of drugs is the fifth most prescribed, approaching 200 million prescriptions per year in the US alone. ACE inhibitors work by preventing the proteolytic cleavage of angiotensin I by ACE to create its active form angiotensin II, which binds to receptors in the walls of blood vessels to initiate their relaxation, reducing...
only need answer for question d and e. thanks 2. Captopril was the first of a...
only need answer for question d and e. thanks
2. Captopril was the first of a class of blood pressure lowering drugs that work by reversibly inhibiting Angiotension-converting enzyme (ACE). Later to the market was Lisinopril. This class of drugs is the fifth most prescribed, approaching 200 million prescriptions per year in the US alone. ACE inhibitors work by preventing the proteolytic cleavage of angiotensin I by ACE to create its active form angiotensin II, which binds to receptors in...
HPI: A 28 YO HM presents to the physician's office for evaluation of a rash on his chest and back. He started with one o...
HPI: A 28 YO HM presents to the physician's office for evaluation of a rash on his chest and back. He started with one oval-shaped purplish area that he thought was a bruise but has subsequently developed multiple new lesions. The growths do not hurt, itch, or bleed, but he continues to get new ones, and the existing ones are getting larger. He has never had anything like this before, has no history of allergies and denies exposure to any...
Interpret this data. Why do you think bone marrow cells would be
affected more than other cell types?
4. The data below helps us to understand both how AZT affects the enzyme that you named above and how it may affect other cells. Interpret this data in light of your answers to the previous questions. Why do you think bone marrow cells would be affected more than other cell types. Fraction of Enzyme bound to Inhibitor Human DNA dependent RNA...
4. A) At high doses, AZT had serious side effects especially on bone marrow cells. Based on the structure of AZT and how you think the inhibitor works, what do you think is the cause? B) The data below helps us to understand both how AZT affects the enzyme reverse transcriptase and how it may affect other cells. Interpret this data in light of your answers to part a. Why do you think bone marrow cells would be affected more...
At pharmaceutical companies the goal of many drug discovery experiments is to find improved drugs over existing drugs that bind to a target protein of interest. The graph below shows how "Drug A" binds to a target protein 1. Protein-Ligand Binding Curve for "Drug A" 1 0.9 0.8 0.7 0.6 Y 0.5 0.4 0.3 0.2 0.1 0 0 10 15 20 25 30 35 40 From the graph, estimate the Kd of "Drug A" for the target protein. Report the...
Please help me with these two problems. I will rate the
answers.
1. The HIV-1 protease, an important enzyme in the life cycle of the human immunodeficiency virus-1 (HIV-1), is a good drug target for the treatment of HIV and AIDS. A protein produced by the virus, p6*, is an HIV-1 protease inhibitor. The activity of the HIV-1 protease was measured in the presence and absence of p6* using an assay involving an artificial substrate, as shown below. NH Lys...
Homework # 16: Enzymes Late assignment will be given a grade of "0. Due Date 1. An enzyme is primarily made out of a (hint what food group). catechol+ oxygen (0a) Catecholasepolyphenol 2. Looking at the equation above, the enzyme in this reaction is: 2. A. Catechol B. Oxygen C. Catecholase D. Polyphenol 3. Looking at the same equation as question 2, what is the substrate? A. Catechol B. Oxygen C. Catecholase D. Polyphenol What is the name of the...
Question 1 (1 point) Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One way to treat high blood pressure is to administer competitive inhibitors that bind to this receptor. The Kd for binding of epinephrine to this receptor is ~UM. Based on the measured affinity (Kd) of the following drugs for the a-adrenergic receptor, which might be good candidates for high blood pressure medication? Drug A: Kd = 0.6 M; Drug B: Kd...
2. Captopril was the first of a class of blood-pressure lowering drugs that work by reversibly inhibiting Angiotension-converting enzyme (ACE). Later to the market was Lisinopril. This class of drugs is the fifth most prescribed, approaching 200 million prescriptions per year in the US alone. ACE inhibitors work by preventing the proteolytic cleavage of angiotensin I by ACE to create its active form angiotensin II, which binds to receptors in the walls of blood vessels to initiate their relaxation, reducing...
only need answer for question d and e. thanks
2. Captopril was the first of a class of blood pressure lowering drugs that work by reversibly inhibiting Angiotension-converting enzyme (ACE). Later to the market was Lisinopril. This class of drugs is the fifth most prescribed, approaching 200 million prescriptions per year in the US alone. ACE inhibitors work by preventing the proteolytic cleavage of angiotensin I by ACE to create its active form angiotensin II, which binds to receptors in...
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