Question

Why all major drugs currently in clinical trials modulate protein phosphorylation – unfortunately, (<90%) will fail? What is attractive about ubiquitin ligases in comparison to kinases/phosphatases with respect to drug development?

Answer 1

The ubiquitin ligase helps in tagging of foreign particles or antigen with ubiquitinin. As ubiquitin is attached to a antigen , it is directed to proteasome complex which degrades it and transform it into peptide fragmments which then presented as outside the cell with MHC and induce antibody development. Similarly new drugs will be displayed with MHC which will act as vaccine and induce antibody development. These antibodies will protect body when real antigen will enter the body in due course of infection.