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A cell makes a mistake during DNA replication and ends up with two NON-IDENTICAL copies of its DNA. If everything is working
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If a cell has not properly copied its chromosomes or there is damage to the DNA, the CDK will not activate the S phase cyclin and the cell will not progress to the G2 phase. The cell will remain in S phase until the chromosomes are properly copied, or the cell will undergo programmed cell death.

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