Question

You are consulting with a family where sometimes a mutation that leads to deafness (D) and a mutation that predisposes individuals to early heart failure (H) are linked. Normally these two traits sort independently but, in some individuals, a reciprocal translocation has moved them to the same chromosome. The chromosome maps for an individual with two normal chromosome pairs (Normal Arrangement), and a translocation heterozygote (Translocation Arrangement) are shown below. Deafness and early heart failure are both inherited in a dominant fashion (with respect to hearing and normal heart function). However, deafness is normally present at birth and early heart failure occurs on average at 40 years of age. A pedigree of the family is shown below. Below are chromosome maps (centromeres shown as blue dot) and pedigrees. Use what you know about translocation heterozygotes, and the chromosome maps and pedigrees, to answer the questions that follow. Note: The images are also in a separate PDF file (with text descriptions) posted under the Online Tutorial #2 link on Moodle. 1 Normal arrangement Translocation arrangement " O 1 O XXO 3 4 5 6 Dear O Early heart failure J E DH --> Chromosome with translocation 2 III U Chromosome with translocation NO 1

Answer 1

Ansuler or correct answer is ophon' d' >50%, both Explanation. Depending on the type of Segregation gannetes will be liable. if Segregation is adsia Cent Since in types of gamets have the same likelyhood of happening to the segregation is alternative the gamites will be inviable. - Now ganels have the same likely hood of being Nicable and inviable (50%). If the

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12) Consider translocation belowozygous as - Odth 'normal homozygous as - ddhh. - there is no crossing over blw D and Hin helesozygous. so, the gamete will be ob dH. In normal individual 'the ganuele will be dh, dh. Ela doawing a punnet Square we get. - an I dn Dh I Dahh Dd bh dd Hh dd hh from the above square we get that som. - 'deafness sor. – Ecally hecat failure.

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