Question

1 point Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for many metabolic reactions. Lack of the precursor to NAD+, niacin, results in the human disease called pellagra, thus humans have evolved salvage pathways to breakdown and re-synthesize NAD+ when needed. Below is the chemical structure of NAD+. Enzymes catalyze reactions in parts of the protein called an active site. This portion of the protein forms favorable weak interactions with the substrate and stabilize the transition state, which is crucial for accelerating the reaction kinetics. Draw how an enzyme active site could bind NAD+. Remember you are limited to the 20 amino acids and their side chains. Also, no free floating amino acids, they all are part of the same protein so show the "enzyme cave" to indicate that they are in the same chain of amino acids. Describe how your enzyme binds to the substrate. *

Answer 1