Question

Select all that apply to Sideroblastic anemia.

	dimorphic RBC population
	hypersegmented PMNs
	ringed sideroblasts in the bone marrow
	negative Prussian Blue in the bone marrow
	siderocytes on a peripheral smear
	increased ferritin

Answer 1

SIDEROBLASTIC ANEMIA

1)DIMORPHIC RBC POPULATION

2) RINGED SIDEROBLAST IN THE BONE MARROW

3)SIDEROCYTE IN THE PERIPHERAL SMEAR

4)INCREASED FERRITIN

DIMORPHIC RBC POPULATION

Congenital sideroblastic anemia usually exhibits dimorphic red cells (normocytic normochromic and microcytic hypochromic).

RINGED SIDEROBLAST IN THE BONE MARROW

ringed sideroblast are the cells that arrange iron granules in a ring form around the nucleus.This can be seen in the aspirate from the bone marrow.

SIDEROCYTE IN THE PERIPHERAL SMEAR

siderocyte are abnormal red blood cell that has iron granules that are not part of the hemoglobin.This can be seen in anemia related to increased iron storage like sideroblastic anemia and thalasemia

INCREASED FERRITIN

in sideroblastic anemia

Hb is reduced

serum iron is increased

ferritin is increased

total iron binding capacity will be normal

hypersegmented PMNs are seen in megaloblastic anemia not in sideroblastic anemia.

The specific test used in the sideroblastic anemia is the prussian blue test,it will be positive in sideroblastic anemia.

we can see Ringed sideroblast in the bone marrow in this test.