Question

w window Help Q-BIGA Exercise 4-S20 FILLABLE (1).pdf (page 11 of 11) Q Search 10 9. There are several naturally occurring mutations in Hb. Some of the mutations are benign (harmless) while others cause serious health problems for the individuals who carry them. Provide a plausible reason for the observations in one of the different Hb variants below. Consult the figure in question 5 to help you in formulating your answer. Mutation Mutation Name Hb Hammersmith F42S in B subunits Hb Bristol V67D in B subunits Consequence The heme group is easily dislodged from its hydrophobic binding pocket. The protein is destabilized (and ultimately causes premature lysis of erythrocytes (hemolytic anemia)] Individuals have chocolate brown blood; Hill coefficient of -1.2. HDM lwate H93Y in a subunits

Answer 1

Hemoglobin s

The Hydrophobic Pocket of the Hemoglobin S Molecule

Sickle hemoglobin differs from normal hemoglobin by a single amino acid: valine replaces glutamate at position 6 on the surface of the beta chain. This creates a new hydrophobic spot The polymerized hemoglobin distorts red blood cells into an abnormal sickle shape