Question

1. Integrins are surface / cytoplasmic (circle one) proteins that play an important role in holding

   together ____________________.
   
   11. Which one of the following is not a factor that affects the amount of adhesion by cadherins?

   1. The organizing of cadherins in the membrane

   2. The activation state of cadherins

   3. The number of cadherins

   4. The amount of overlap between cadherin extracellular domains

18. Explain how altering the expression of selectins allows leukocytes to recognize inflamed epithelia.

19.Selectins exhibit homophilic / heterophilic binding, as they recognize _________________.

Answer 1

Ans :-

Integrins are surface/cytoplasmic (circle one) proteins that play an important role in holding together cytoskeleton and extracellular matrix.

11. The activation state of cadherins

Reason:- Adhesion referring to the direct effect of cadherins on interfacial tension, not related to chemical binding.

18. Selectins are involved in inflammation processes.There are three members of the selectin

a) L-selectin in Leukocytes, b) E-selectin in Endothelial cells, c) P-selectin in Platelets

• The L -selectins on the surface of leukocytes bind to carbohydrates causing the cells to roll along the blood vessel walls, slowing their motion and enabling them to enter the site of infection.

19. Selectins exhibit homophilic/heterophilic binding, as they recognize Carbohydrate ligands called siaiyl Lewis X(sLex) tetrasaccharide.