Question

The picture below schematically depicts proteins containing various types of signals and topogenic sequences. Predict the arrangement of each type of protein shown in the figure with respect to the endoplasmic reticulum membrane and lumen.  Provide the drawings.

Cleavable signal sequence (a) N Noncleavable = signal-anchor sequence Stop-transfer sequence (b) N4 DNA - C (d) NHH (e) N-

Answer 1

+ Auswere a cytosol I IER Lumen cytosd ER membrane et just contains the cleavable signal sequence So, the whole whole protun will be inside the ER lumen I - cytosol ER Lumen & b y a cytosol. Contains only one cleavable signal anchor sequence. So, the protun will go inside the ER and will be anchoed to the inner membrane only - cytosol Er lumen l cytosol - Contains clearable signal sequmes. So this part will cross, the membrane but is followed by a stop just outside wi tronsber Tequince. where the tremster will stop, so it will be a single pass trongmembrane protein.

cytosol ER lumen cytosol → The & sign will face the membrane. put the box the first box just inside the membrane and the second box just outside with the intermediate protein inside the membrane. - The third box is a stop tronster sequence. So, it will remain outside the membrane. The bulth box will be one the outer membrane and it enters from the plus sign. Then last bon prevents the entry and will remain on outside membrane es cytosol ER lumen I cytosol → The first box will be inside the membrane. The Second bore į Slop transfer to, it will be outside till the third box which will get inside and the last box will stop sequence. The rest part of the protein remadus outside. → 50, the nutshell, think like this + part goes inside the box membrane the stop remains in the Jaquune remains, outside the membrane lear Rate my Answer