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Professor Owen made an astute observation: In outbred cattle, dizygotic twins that share the same placenta...

Professor Owen made an astute observation: In outbred cattle, dizygotic twins that share the same placenta occur occasionally. Indeed, if one examines peripheral blood samples from such twin pairs, each has blood cells derived from the other, indicating shared circulatory systems in utero. Surprisingly, even though they are not genetically identical, they accept tissue grafts from one another.

Inasmuch as these are dizygotic twins and thus are not genetically identical, does their mutual graft acceptance violate the "isografts succeed, allografts fail" rule?

What does this experiment tell you about the underlying mechanism of that last property of the immune system - non-responsiveness to "self?"

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It is known that isografts are better than allografts due to the higher chances of survival but the allografts are also possessed a significant survival rate i.e. up to 84%. The isografts are called better because identical bodies will have the same immune system. However, if allografts become successful and there is no immunogenic response in the acceptor body, then it will be a good experiment. Therefore, if the given experiment is to succeed, then there will be no objection.

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