Question

Questions 26 and 27 please

26. Two phenotypically unaffected parents produce two children with familial Down syndrome. With regard to chromosomes 14 and 21, which genotype pairing could NOT be the parents in this family: A. B. Male 14, 21 and T(14;21) - Male T(14;21) and T(14;21) - Male 14, 21 and T(14;21) - Male 14, 14, 21, 21 Female 14, 14, 21, 21 Female 14, 14, 21, 21 Female 14, 21 and T(14;21) Female 14, 21 and T(14;21) C. 27. Many leukemia patients have mutant, hyperactive, forms of the c-abl gene. What type of chromosomal rearrangement typically accounts for these mutations?

Answer 1

Answer 27. During the malignant transformation of myeloid cells, a portion of chromosome 9 that contains the abl locus translocates to chromosome 22 at the breakpoint cluster region gene and generates the chimeric BCR-ABL gene. Type of chromosome rearrangement is chromosomal translocation