Question

Question 15 2 pts Myasthenia gravis is an autoimmune neuromuscular disease that results in muscle weakness caused by circulating antibodies that block acetylcholine receptors. People with the disease are treated with acetylcholinesterase inhibitors or immunosuppressants. Use several sentences to explain why acetylcholinesterase inhibitors work, what possible side effects they might have, and a potential mechanism for those side effects. HTML Editor B I V A E 3 1 1 1 x 5 E - A - IX N V x 12pt V Paragraph .

Answer 1

Ans : Functioning of acetylcholinesterease inhibitor(AChEI)

it is an inhibitor that inhibits acetylcholinestrease from breaking down acetylcholine into choline and acetate ,thereby increasing both level and duration of action of the nuerotransmitter acetylcholine in central nervous system ,auotonomic ganglia,and neuro musular junctions which are rich in acetylcholine receptors.

Side effects and its mechanism,

• Bradicardia,hypotension,hyper secretion,bronchoconstriction : Action on the parasympethatic nervous system.
• cholinergic crisis
• Action of neuoromuscular junction will results in prologed muscle contraction.
• Administration of reversible cholinoesterase inhibitor is contraindicated with those that have urinary retention due to urethral obstruction.
• Severe side effects are mainly ,nausea,vomiting,:stimulation of the gut chemoreceptors and stretch recepters triggers via vagal nerve afferent and afferent fibres associated with sympethetic nnervous system.In addition to being neuro trsmitter that stimultes nausea annd acetylcholine also increases gut motility and seretion.