please indicate what happens during each step (hence why im
confused)
1. Suppose that vampires actually...
1. Suppose that vampires actually exist and that the condition is caused by a prion disease that eliminates the ability to manufacture red blood cells (RBC) by changing their body's DNA throughout the bone marrow. They need to drink blood in order to replenish their RBC count. RBC are normally produced in the bone marrow and destroyed in the spleen once they have existed for about 4 months. Sketch a diagram of the regulatory pathways, including feedback loops, described here: The number of red blood cells (RBC count) in the body is the variable being regulated. Over time, the number of RBC decreases due to the action of the spleen. However, if exposed to sunlight, which triggers activation of Vitamin D, which in vampires dramatically raises the Ca++ concentration in plasma, triggering apoptosis (cell death) of RBC so sunlight is a stimulus that will decrease RBC. The kidneys have nerve endings that detect blood O2 levels as a measure of RBC count and release the hormone erythropoietin (EPO) to stimulate release of RBC from the bone marrow. However, in vampires the bone marrow cannot make more cells. They have evolved a mechanism where the release of EPO triggers a diversion of blood flow away from the spleen to slow the rate of RBC destruction. Also, detection of low RBC count triggers the brain to release the hormone vampyrine which causes the sensation of hunger. If the vampire feeds, levels of RBC go up since they are not digested but transported into the blood vessels. (8 points)