Question

please I need to answer this in a full paragraph.

What is necessary in an enzyme’s active site in order for a symmetric molecule to react asymmetrically with the enzyme? Please provide an example of this phenomenon using an enzyme from the citric acid cycle.

Answer 1

Answer-Large scale confirmational change is common in the catalytic cycles of enzymes.Many enzymes functions as homodimers with active site from both the chains.Symmetric and asymmetric cooperative motions in homodimers lead to the opening /closing likely to be valuable for ligand binding and release. Example-citrate synthase catalyses the introduction of carbon into the citric acid cycle through condensation of acetyl-coA with oxaloacetate to form citrate .