Question

This question is in the context of induced response of Innate Immunity.

There are many examples where our immune system "over responds" to pathogen insult and causes severe damage or death. An example is seen below where mice injected with a lethal dose of Gram negative 018 E coli will die within 5 days from multiple organ failure. In contrast, mice in which one of the Pattern Recognition Receptors is deleted/knocked out (PRRX) are actually protected from the lethal dose of E coli (Note: The PRRx and SAM KO lines overlay in the right graph and are 100% across the entire time period.. A deletion of the TLR2 is shown as a control. In addition, a deletion of a signaling adaptor molecule also protects the mice from the lethal dose of E coli. Given the information in the experiment below, what are the identities of PRRX and SAM? PRR X SAM The pathology shown in the experiment below is called ? Mice Survival After E Coli Infection Effect of E Coli on TNF Production 16 100 14 90 12 BO 70 10 WT 60 TNF (ng/ml) TLR2 KO % Survival 50 PRRX KO 6 40 SAM KO 4 30 20 2 10 0 WT TLR 2 KO PRRX KO SAM KO 0 0 1 5 3 Days