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According to hardy weinberg equilibrium, when mating occour in large population with no disruptive forces, both allelic frequency and genotype will remain constant because they are in equilibrium. This principle distrupt by no. Of forces such as mutation, natural selection, nonrandom mating , genetic drift and gene flow.

Natural selection and nonrandom mating occur due to change in allelic frequency , this occur because certain allele help or harm reproductive success.

Nonrandom mating leads to a genetic drift occur in small population, when allelic frequency grow lower or heigher by chance. Here the main biological phenomenon is genetic drift.

So , the answer is yes one mating change the gene pool for another mating due to no. Of forces.

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