Question

The function of the beta subunit is to prevent DNA polymerase III from dissociating from the template DNA strand while still allowing the polymerase to slide along DNA as replication progresses. Given this function, the alpha helices in the beta subunit are

The function of the beta subunit is to prevent DNA polymerase III from dissociating from the template DNA strand while still allowing the polymerase to slide along DNA as replication progresses. Given this function, the alpha helices in the beta subunit are

located on the inner surface and oriented parallel to the minor and major grooves of DNA.

located on the inner surface and oriented perpendicular to the minor and major grooves of DNA.

located on the outer surface and do not interact with DNA.

Answer 1

Answer: The alpha helices in the beta subunit are located in the inner surface and are orientated perpendicular to that of major and minor grooves of DNA. The perpendicular orientation of the alpha helices helps in restricting the access of the protein to the major and minor grooves of DNA and thus facilitates sliding of the beta subunit along the DNA. Therefore, the correct option is B.