Question

Secreted or membrane-bound proteases can provide another simple, yet effective resistance strategy against antimicrobial peptides, by effectively cleaving and inactivating them. why nowadays ,many antimicrobial peptides still can be used in the antimicrobial area and as a novel drug to kill bacterila? and the antimicrobial peptides how to avoid the proteases to inactivating it???

Answer 1

AMPs usually undergo intracellular proteolytic degradation, increase virulence of the bacteria by increasing the expression of the virulent gene. This makes them unfit for invasive diseases because the bacteria can easily counter them and can grow resistance.

However, they can be a promising treatment for topical disease treatments because they do not undergo degradation on the external surface of the body. From a pharmaceutical perspective, the AMPs can be widely used to treat topical diseases such as the skin and wound diseases. Topical application cancels out the chances of being degraded in the body due to proteolytic degradation and also decreases the chances of systemic toxicity inside the body. AMPs, therefore, can be also used largely to kill bacteria on an antimicrobial surface.