Question

10 pts Question 47 Starting from Alpha Ketoglutarate make Ribose-5-Phosphate Instructions for entering answers: . Any major substrate you wish to use, you must have been provided or your must shown it being made. • Provided materials do not necessarily need to be used in the pathway. . Do not use capitals or punctuation (e.g. acetyl coa is correct Acetyl-CoA will be marked wrong) Do not separate obvious prefixes from the rest of the name (hexokinase is correct hexo kinase will be marked wrong) . Do not use Greek letters (a ketoglutarate dehydrogenase is correct) use the corresponding English letter (e.g. alpha = a, beta = b. gamma = g. delta = d) . Do not use the word "complex" • Enter only main metabolites do not enter side products (e.g. ATP. NADH) . Starting substrate: alpha ketoglutarate Ending Material: ribose 5 Phosphate Provided Materials: None Enzyme Product

Starting from Alpha Ketoglutarate please make Ribose-5-Phosphate by listing enzymes in the step and products.

Answer 1

The following table shows the enzymes and products formed in production of ribose-5-phosphate from alpha ketoglutarate :

Here, succinyl coa is formed from alpha ketoglutarate (alpha ketoglutarate is formed from isocitrate).

Enzyme	Produst
a ketoglutarate dehydrogenase	succinyl coa
succinyl coa synthetase	succinate
succinate dehydrogenase	fumarate
fumarase	malate
malate dehydrogenase	oxaloacetate
phosphoenol pyruvate carboxykinase	phosphoenol pyruvate
enolase	2-phosphoglycerate
phosphoglycerate mutase	3-phosphoglycerate
phosphoglycerate kinase	1,3-bisphosphoglycerate
glyceraldehyde-3-phosphate dehydrogenase	glyceraldehyde-3-phosphate
aldolase	fructose 1,6 bisphosphate
fructose 1,6 bisphosphatse-1	fructose-6-phosphate
phosphoglucose isomerase	glucose-6-phosphate
glucose-6-phosphate dehydrogenase	6-phosphogluconolactone
gluconolactonase	6-phosphogluconate
6-phosphoglucinate dehydrogenase	ribulose 5 phosphate
ribulose 5 phosphate isomerase	ribose 5 phosphate

Thus, ribose 5 phosphate is formed from a ketoglutarate [i.e, from Citric acid cycle (a ketoglutarate to oxaloacetate) followed by Glyconeogenesis(oxaloacetate to glucose 6 phosphate) and atlast Penrose phosphate pathway( from glucose 6 phosphate to ribose 5 phosphate) ].