HomeworkLib
Question

Low stem cell yield is a significant issue following cord stem cell transplant for haematological conditions....

Low stem cell yield is a significant issue following cord stem cell transplant for haematological conditions. Discuss the methods that have been implemented and those that are currently under investigation to improve outcome following cord stem cell transplantation in relation to improvements in the CD34+ cell dose provided.

science   biology   
0 0
Add a comment Improve this question Transcribed image text
Next > < Previous
Sort answers by oldest

Homework Answers

Answer #1

Stem cell transplantation has three different rich sources such as umbilical cord blood, bone marrow and peripheral blood. Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases.The first umbilical cord blood transplantation was done in october 1988. Umbilical cord is one of the richest sources of stem cells and is isolated from the infant during birth without damaging the umbilical cord. Based on the age, weight, disease status of the patient the number of cells to be engrafted for successful transplant are decided.

A cord blood unit might contain too few stem cells for the recipient’s size. Due to the smaller number of stem cells in the cord blood unit, cord blood stem cell transplants engraft more slowly than stem cells from marrow or peripheral blood. Compared with bone marrow (BM) cells, CD34+/CD38? Umbilical cord blood cells proliferate more rapidly and generate larger numbers of progeny cell.

TNC and CD34+ are considered to be the best predictors of engraftment standard for selection of units.Total nucleated cell (TNC) and CD34+ cell doses in cord blood grafts are highly correlated with the rate of neutrophil and platelet engraftment, as well as the incidence of graft failure and early transplant-related complication. Critical cell-dose thresholds have been established and outcomes for patients receiving less than the generally accepted threshold of over 2.5 × 107 TNC/kg are significantly inferior in terms of engraftment, transplant-related mortality and overall survival.

Improvements are being made upon for the betterment of outcome of the stem cell transplant therapy.

0 0
Add a comment
Know the answer?
Add Answer to:
Low stem cell yield is a significant issue following cord stem cell transplant for haematological conditions....
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for? Ask your own homework help question. Our experts will answer your question WITHIN MINUTES for Free.
Similar Homework Help Questions

  • An epidemiologic profile is a summary of a significant public health issue, or issues, in your...

    An epidemiologic profile is a summary of a significant public health issue, or issues, in your community, county, state, or country. An epidemiological profile helps to coordinate activities and policies from various agencies and organizations to improve health. Review the available data, reports, and documents for your locale. Assess how the methods of epidemiology (study designs, data collection, measures of association, etc.) are used to determine who needs what services, where the services are needed, and how those services should...

  • My Study on Sickle Cell Anemia Research In 500 words, answer the following questions 1.Select your...

    My Study on Sickle Cell Anemia Research In 500 words, answer the following questions 1.Select your study sample 2. How have you selected your sample? 3. How will you select your sample population and give the rationale behind your decision Please type the solution on the keyboard so that I can copy and paste Q. No 1. Answer : Sickle cell disease : It is defined as it is a chronic heriditory form of Anemia, in which the red blood...

  • Groups influencing the Long case Issue 1: The on-field implications of the AFL policy AFL Players...

    Groups influencing the Long case Issue 1: The on-field implications of the AFL policy AFL Players’ Association .The AFL Players’ Association (AFLPA) had a limited role in the debate surrounding the Long case. The confrontation between Long and Monkhorst (two players registered as AFLPA members) restricted the AFLPA’s ability to act. On establishment of a policy and adequate resolution to the issue, the AFLPA provided support. The implications of this issue for the AFLPA could have been far-reaching if Long...

  • [The following information applies to the questions displayed below.] In the largest criminal tax case ever...

    [The following information applies to the questions displayed below.] In the largest criminal tax case ever filed, KPMG admitted it engaged in a fraud that generated at least $11 billion dollars in phony tax losses, which, according to court papers, cost the United States at least $2.5 billion dollars in evaded taxes. In addition to KPMG's former deputy chairman, the individuals indicted included two former heads of KPMG's tax practice and a former tax partner in the New York City...

  • Entering and Contracting Contracting at Charity Medical Center Charity Medical Center (CMC), a five hundred-bed acute-care...

    Entering and Contracting Contracting at Charity Medical Center Charity Medical Center (CMC), a five hundred-bed acute-care hospital, was part of the Jefferson Hospital Corporation (JHC). JHC, which operated several long-term and acute-care facilities and was sponsored by a large religious organization, had recently been formed and was trying to establish accounting and finance, materials management, and human resources systems to manage and coordinate the different facilities of particular concern to CMC, however, was a market share that had been declining...

  • 10. Write a one-page summary of the attached paper? INTRODUCTION Many problems can develop in activated...

    10. Write a one-page summary of the attached paper? INTRODUCTION Many problems can develop in activated sludge operation that adversely affect effluent quality with origins in the engineering, hydraulic and microbiological components of the process. The real "heart" of the activated sludge system is the development and maintenance of a mixed microbial culture (activated sludge) that treats wastewater and which can be managed. One definition of a wastewater treatment plant operator is a "bug farmer", one who controls the aeration...

  • summatize the following info and break them into differeng key points. write them in yojr own...

    summatize the following info and break them into differeng key points. write them in yojr own words   apartus 6.1 Introduction—The design of a successful hot box appa- ratus is influenced by many factors. Before beginning the design of an apparatus meeting this standard, the designer shall review the discussion on the limitations and accuracy, Section 13, discussions of the energy flows in a hot box, Annex A2, the metering box wall loss flow, Annex A3, and flanking loss, Annex...

  • The Mayo clinic is one of the most respected names in medicine world. Founded in the...

    The Mayo clinic is one of the most respected names in medicine world. Founded in the 1880s in Rochester, Minnesota, the Mayo clinic embraced innovation from the beginning. It is believed to be America’s first integrated group practice as it employed the concept of coordinated, specialized care and sought out the best expertise. At the core of the Mayo culture, from its inception to today, is a team approach and physician decision making rooted in shared responsibility and consensus building....

  • Please summarise the following content:(no word limit) EXPERIMENTAL PROCEDURES Animals All animals including pregnant ICR mice,...

    Please summarise the following content:(no word limit) EXPERIMENTAL PROCEDURES Animals All animals including pregnant ICR mice, neonatal Wistar rats, and NOD-SCID mice (8 weeks old, male) were purchased from CLEA Japan (Tokyo). All exper- imental procedures and protocols were approved by the Animal Care and Use Committee of Keio University and conformed to the National Institutes of Health Guide for the Care and Use of Laboratory Animals. Cells Mouse ESCs were obtained from the Laboratory of Pluripotent Cell Studies, RIKEN...

  • Summary should briefly analyze the central problems and issues of the case and provide some analysis...

    Summary should briefly analyze the central problems and issues of the case and provide some analysis and suggestions. Thank you. Lean Initiatives and Growth at Orlando Metering Company It was late August 2002 and Ed Cucinelli, vice president of Orlando Metering Company (OMC), sat in his office on a late Saturday morning. He had come in to prepare for some strategic planning meetings that were scheduled for the upcoming week. As he noticed the uncommon silence in the building, Ed...

ADVERTISEMENT
Free Homework Help App
Download From Google Play
Scan Your Homework
to Get Instant Free Answers
Need Online Homework Help?
Ask a Question
Get Answers For Free
Most questions answered within 3 hours.
ADVERTISEMENT
ADVERTISEMENT