Question

Insulin and glucagon release from the pancreas is a vital part of the negative feedback loop that regulates blood glucose levels. Let's review how insulin and glucagon release change in response to plasma glucose levels and how that helps keep plasma glucose constant.

† Plasma glucose Plasma glucose Beta cells in pancreas Alpha cells in pancreas Negative feedback Negative feedback 1 Insulin secretion 1 Glucagon secretion . . . . . . . . . . Most tissues Liver and muscle Liver Liver Adipose tissue . . . Gluconeogenesis . 1 Glycogen synthesis 1 Gluconeogenesis 1 Glucose uptake into cells † Lipolysis . . † Glycogenolysis . Glycogenolysis . . † Plasma fatty acids . . I I I Plasma glucose 1 Plasma glucose Glucose spared 0 Initial stimulus Physiological response Result 0 (a) (b)

Drag the labels onto the figure to create a flow chart of how insulin and glucagon release change in different circumstances to keep blood glucose within a normal range.

Reset Help secrete less glucagon secrete less glucagon Decreased plasma glucose Decreased plasma glucose release stored glucose release stored glucose secrete more glucagon secrete more glucagon Increased glucose uptake Increased glucose uptake secrete less insulin secrete less insulin secrete more insulin secrete more insulin Increased plasma glucose Increased plasma glucose

Answer 1

(^ Plasma Glucose & Plasma Glucose beta : Alpha Cells Becrete (less Glucagoh feedback beta Becrete less O Alpha Berrete more 1 Glucagon Lecrete more Insulin Negative Most Cells Increased Uptake If Most Cells Glucose) / Release stored Glucose Increased Plasma Glucose Plasma, Decreased Glucose