It is very important for DNA repair mechanism to be able to recognise the old strand because the new strand should be formed complementary to old strand. It will repair the errors in new strand and correct according to the complementary base pair of old strand.
If this capability are lost then it may repair the old strand as complementary to the new strand instead of vise-versa
9. Why is it important for DNA repair mechanisms to be able to recognize the old...
1. DNA repair mechanisms. A. What are the common themes for all the different repair mechanisms? B. What are the health consequences of inherited mutations in DNA repair pathway proteins? Can you name a couple mentioned in class? Are there others that you know of? 4. Homologous Recombination A. How are the repair of double strand breaks (DSBs) and production of DSBs for recombination connected? B. How does the general model of strand invasion, branch migration, and resolution of the...
DNA mismatch repair enzymes preferentially repair bases on the newly synthesized DNA strand, using the old DNA strand as the template. If mismatches were simply repaired without regard for which strand served as template, would this reduce replication errors? Explain your answer (5 pts) Describe DNA replication (remember to mention all the enzymes involved) (10 pts)
Q1: If DNA damage occurred, the cells repair the damage by several mechanisms during the cell cycle. In which phase of the cell cycle cells will repair the damage? Name five of the repair mechanisms that cells are using to repair DNA damage? What are the repair mechanism for double strand DNA breaks? Describe them and Which of them is the error- free repair pathway?
Why is it important to recognize team problems early? What can happen if not addressed? What are five important things a team member must do to be a good team member? How do you repair a stalled team?
10. During repairs the mismatch repair machinery has to distinguish the old DNA strand from the new strand, how does it do this?
How does the DNA repair mechanism distinguish the old strand from the new strand shortly after replication? A. the old strand is methylated while the new strand is not B. the old strand will contain thymine while the new strand contains uracil C. the new strand is methylated while the old strand is not D. the new strand has amino acids instead of nucleotides
Identify the various types of DNA repair mechanisms known to counteract the effects of UV radiation. Recombinational repair Excision repair Photoactivation repair SOS repair 1. is dependent on a photon-activated enzyme that cleaves thymine dimers. 2. is the process by which an endonuclease clips out UV- induced dimers, DNA polymerase III fills in the gap, and DNA ligase rejoins the phosphodiester backbone. 3. uses the corresponding region on the undamaged parental strand of the same polarity. 4. is a process...
A common feature of DNA repair mechanisms is that the lesion (mutated base, adduct, etc) is removed including the sugar phosphate backbone. Give 2 examples of repair mechanism that do that Why is this a common theme? Ie, why does it make sense that all repair mechanisms reach this same point.
Molecular biology of the gene. From the paper “DNA repair
mechanisms and the bypass of DNA damage in saccaromyces cerevisiae”
3. In general for methyltransferase a. b. What type of damage does it repair? How does it repair the damage? lanhy the damaged guanine woulr hymine nstead of eyriosine
5. About double strand DNA repair, it is correct to say that choose the most appropriate answer): (a) It requires one intact strand as a template for error correction. (b) Mismatches in the DNA are usually corrected via double strand DNA repair mechanisms. (c) Homologous recombination usually results in DNA repair with no loss of nucleotide at repair site. (d) Non-homologous end-joining usually results in DNA repair with no loss of nucleotide at repair site. 6. A eukaryote gene has two introns and three exons....